Fatal Flaws

Fatal Flaws: How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain [Kindle Edition]

Author: Jay Ingram | Language: English | ISBN: B00BQZ1V60 | Format: PDF, EPUB

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Fatal Flaws: How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain
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Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeldt-Jakob disease to Parkinson’s, Alzheimer’s, Lou Gehrig’s, and others.

 

As in each of his best-selling books, Jay Ingram here makes complex scientific concepts accessible and shows how little-known events may have profound significance. He describes the development of prion science as a rough-and-tumble affair, with rivals, eccentrics, interfering governments, and brilliantly creative people all playing salient roles. Weaving biology, medicine, human tragedy, discovery, and bitter scientific competition into his account, he reveals the stunning potential of prion science, whose discoveries may unlock the answers to some of humankind’s most destructive diseases.

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• File Size: 731 KB
• Print Length: 293 pages
• Page Numbers Source ISBN: 0300189893
• Publisher: Yale University Press; 1 edition (March 19, 2013)
• Sold by: Amazon Digital Services, Inc.
• Language: English
• ASIN: B00BQZ1V60
• Text-to-Speech: Enabled
• X-Ray:
  Not Enabled
• Lending: Not Enabled
• Amazon Best Sellers Rank: #511,182 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
  • #54 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Medical eBooks > Basic Science > Biochemistry
  • #74 in Kindle Store > Kindle eBooks > Nonfiction > Science > Biological Sciences > Biochemistry
  • #74 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Professional Science > Biological Sciences > Biochemistry

Excellent coverage of a serious emerging topic. As an outdoor writer struggling to understand CWD (Chronic Wasting Disease, a TSE specific to deer species), and how to communicate with the my readers about them, I have found Fatal Flaws to be an excellent resource.

Unfortunately with the title including nothing about the topic - the word "Prion" prion being absent from the title and subtitle, in fact occurring exactly zero times on the outside of the jacket - I worry that some people looking for information on the topic might miss it.

By Steve Jones

Great book, and easy to follow. It covers some complex science, but the author does a good job of introducing the concepts of protein chemistry ahead of time. This makes it easy to follow, and even a non-scientist can follow the lingo. The level is about that of a Scientific American article, but book-length. If you want to understand the background behind a very important medical problem (one that will be critical in the future), pick this book up.

By John Matta

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