Cluster Randomised Trials

Cluster Randomised Trials (Chapman & Hall/CRC Interdisciplinary Statistics) [Hardcover]

Author: Amazon Prime | Language: English | ISBN: 1584888164 | Format: PDF, EPUB

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Cluster Randomised Trials
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Cluster Randomised Trials discusses the design, conduct, and analysis of health trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomization, with special attention given to evaluating the effects of interventions against infectious diseases.

Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. The authors also present an array of design issues in cluster randomised trials (CRTs), including strategies for minimizing contamination effects, the use of stratification and restricted randomisation to improve balance between treatment arms, special methods for sample size calculation, and alternatives to the simplest two-arm CRT. After covering analytical methods for CRTs, such as regression methods, the authors examine ethical issues, trial monitoring, interim analyses, reporting, and interpretation.

Although the book mainly focuses on medical and public health applications, it shows that the rigorous evidence of intervention effects provided by CRTs has the potential to inform public policy in a wide range of other areas. The book encourages readers to apply the methods to their own trials, reproduce the analyses presented, and explore alternative approaches.

Books with free ebook downloads available Cluster Randomised Trials (Chapman & Hall/CRC Interdisciplinary Statistics) [Hardcover]

• Series: Chapman & Hall/CRC Interdisciplinary Statistics
• Hardcover: 338 pages
• Publisher: Chapman and Hall/CRC; 1 edition (January 12, 2009)
• Language: English
• ISBN-10: 1584350555
• ISBN-13: 978-1584888161
• ASIN: 1584888164
• Product Dimensions: 9.3 x 6.3 x 0.9 inches
• Shipping Weight: 1.4 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #1,027,588 in Books (See Top 100 in Books)

This is a "must have" book for any busy clinician participating in clinical trials. The authors have done an admirable job of keeping the math to a minimum while still including enough to provide statistical heft.

With large clinical trials becoming ubiquitous in modern evidence-based medicine, understanding the information generated by statistical analysis of the data generated by these studies will be essential for the practitioner as well as the hardened researcher.

By David Robbins Tien

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