Showing posts with label Research. Show all posts
Showing posts with label Research. Show all posts
Wednesday, May 7, 2014

Measuring Health


Measuring Health: A Guide to Rating Scales and Questionnaires [Kindle Edition]

Author: Ian McDowell | Language: English | ISBN: B0054ID992 | Format: PDF, EPUB

Measuring Health: A Guide to Rating Scales and Questionnaires
You can download Measuring Health: A Guide to Rating Scales and Questionnaires for everyone book mediafire, rapishare, and mirror link Worldwide economic constraints on health care systems have highlighted the importance of evidence-based medicine and evidence-based health policy. The resulting clinical trials and health services research studies require instruments to monitor the outcomes of care and the output of the health system. However, the over-abundance of competing measurement scales can make choosing a measure difficult at best. Measuring Health provides in-depth reviews of over 100 of the leading health measurement tools and serves as a guide for choosing among them.LNow in its third edition, this book provides a critical overview of the field of health measurement, with a technical introduction and discussion of the history and future directions for the field. This latest edition updates the information on each of the measures previously reviewed, and includes a complete new chapter on anxiety measurement to accompany the one on depression. It has also added new instruments to those previously reviewed in each of the chapters in the book.LChapters cover measurements of physical disability, social health, psychological well-being, anxiety, depression, mental status testing, pain, general health status and quality of life. Each chapter presents a tabular comparison of the quality of the instruments reviewed, followed by a detailed description of each method, covering its purpose and conceptual basis, its reliability and validity and, where possible, shows a copy of the actual scale. To ensure accuracy of the information, each review has been approved by the original author of each instrument or by an acknowledged expert. Direct download links available for Measuring Health: A Guide to Rating Scales and Questionnaires [Kindle Edition]
  • File Size: 10114 KB
  • Print Length: 768 pages
  • Publisher: Oxford University Press, USA; 3 edition (February 24, 2006)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B0054ID992
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Enabled
  • Amazon Best Sellers Rank: #957,194 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
In an era of accountability, McDowell and Newell do an excellent job of pulling together instruments to assess patients' health. Although this volume was primary designed for Occupational and Physical Therapists, it should have a broader audience. It includes over 80 instruments with a summary on how to employ each device with estimates of reliability and validity. They give more than adequate details to enable the professional to make decisions regarding the quality and appropriateness of each single measure. Users of these tools need to comprehend the extreme lengths that it took for McDowell and Newell to accomplish their task. Their work is truly impressive. On pages 47-50, the authors do a particularly good job explaining the difference between ADL and IADL.
In addition, the authors do a particularly good job in providing technical details needed by professionals to make decisions about the need and appropriateness of an instrument to serve the specific needs of a patient. Students who are learning about calibration of psychometric instruments will also find the work beneficial. They will immediately see the practical application of theoretical concepts presented in classroom decisions. I have placed this fine book on closed serve for students to use after my presentation on reliability and validity.
Every university library should adopt a copy this is fine monograph.
By S. M Marson
... Which is suppose is not a big deal for a book that has to cover all of health. It did describe 8 scales that covered anxiety in general, however. If I needed to chose a scale to measure anxiety for an important project then I would definitely see what this book had to offer. If you wanted a book about health scales but not about SPECIFIC health scales, then I would go for Streiner and Norman.

My copy of the book seemed to have been printed with a laser printer and not had the toner fused to the paper. The print smudged if I rubbed it with a finger and I could completely erase a word if I tried to use a highlighter pen to highlight it! It was, "Printed in the United States of America on acid-free paper". Oopsie. Maybe they could learn something from Alphapress and have their books printed on demand by Amazon!

The introduction to the Anxiety chapter made a nonsensical and unreferenced distinction between anxiety and fear. It also makes naive comments about who uses dimensional and categorical scales.

I recommend that if you are thinking of getting this book, that you first consider Measures for Clinical Practice and Research by Fischer and Corcoran, also published by OUP, but printed with actual ink. It is huge, 2 volumes, about 1400 pages, and has lots more scales.
By Pen Name and That A

Measuring Health: A Guide to Rating Scales and Questionnaires Download

Please Wait...
Tuesday, May 6, 2014

Measuring Health


Measuring Health: A Guide to Rating Scales and Questionnaires Hardcover – March 9, 2006

Author: Visit Amazon's Ian McDowell Page | Language: English | ISBN: 0195165675 | Format: PDF, EPUB

Measuring Health: A Guide to Rating Scales and Questionnaires – March 9, 2006
Direct download links available Measuring Health: A Guide to Rating Scales and Questionnaires – March 9, 2006 from with Mediafire Link Download Link

Review


"McDowell's learned input contributes substantially to the status of this text as a 'must have'...This is an extensively researched text with an exhaustive offering of measurement principles and approaches. Clinicians, researchers, and psychometrists will value the review of scales and the evaluative commentary offered by the clearly knowledgeable Ian McDowell."--PsycCRITIQUES


"Ian McDowell has crafted a real masterpiece with this, the 3rd edition of his magisterial overview of the science--and to put it mildly, it knocks the socks of almost all the (admittedly limited) competition...The description of concepts and the presentation of pertinent material provide the reader with a well-balanced portfolio of essential intelligence...should be required reading for all newcomers to the subject and might well repay the occasional visit from older hands too."--Public Health


About the Author

Ian McDowell is at University of Ottawa.

Books with free ebook downloads available Measuring Health: A Guide to Rating Scales and Questionnaires Hardcover – March 9, 2006
  • Hardcover: 768 pages
  • Publisher: Oxford University Press; 3 edition (March 9, 2006)
  • Language: English
  • ISBN-10: 0195165675
  • ISBN-13: 978-0195165678
  • Product Dimensions: 10.2 x 7.2 x 1.6 inches
  • Shipping Weight: 3.4 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #411,834 in Books (See Top 100 in Books)

Measuring Health: A Guide to Rating Scales and Questionnaires – March 9, 2006 Download

Please Wait...
Sunday, May 4, 2014

Manual of Research Techniques in Cardiovascular Medicine


Manual of Research Techniques in Cardiovascular Medicine [Kindle Edition]

Author: Hossein Ardehali Roberto Bolli Douglas W. Losordo | Language: English | ISBN: B00HFRG50K | Format: PDF, EPUB

Manual of Research Techniques in Cardiovascular Medicine
Download books file now Manual of Research Techniques in Cardiovascular Medicine for everyone book mediafire, rapishare, and mirror link While some research methods or techniques are applicable in several areas of medicine, research in cardiovascular diseases requires knowledge of an increasing array of procedures, techniques and measurements that are highly specialized and unique to this area of investigation. Edited by senior clinical investigators who are recognized leaders in cardiovascular medicine worldwide, this book provides readers with a comprehensive, practical “how-to-do-it” review of best-practice techniques for cardiovascular research. Download latest books on mediafire and other links compilation Manual of Research Techniques in Cardiovascular Medicine [Kindle Edition]
  • File Size: 14179 KB
  • Print Length: 472 pages
  • Publisher: Wiley-Blackwell; 1 edition (December 16, 2013)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B00HFRG50K
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Enabled
  • Amazon Best Sellers Rank: #1,724,518 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Manual of Research Techniques in Cardiovascular Medicine Download

Please Wait...

Manual of Research Techniques in Cardiovascular Medicine – March 17, 2014


Manual of Research Techniques in Cardiovascular Medicine Hardcover – March 17, 2014

Author: Hossein Ardehali | Language: English | ISBN: 0470672692 | Format: PDF, EPUB

Manual of Research Techniques in Cardiovascular Medicine – March 17, 2014
Download Manual of Research Techniques in Cardiovascular Medicine – March 17, 2014 for everyone book 4shared, mediafire, hotfile, and mirror link

From the Back Cover

While some aspects of clinical and scientific research are common across medicine, research in cardiovascular diseases requires knowledge of an increasing array of procedures, techniques, models and measurements that are highly specialized and unique to this area of investigation. Edited and written by senior investigators, many of whom have been involved in pioneering studies in cardiovascular disease, this new book provides today’s cardiology research professionals with practical how-to guidance on designing, conducting, measuring and reporting their research.

Manual of Research Techniques in Cardiovascular Medicine:

• Reviews the must-know techniques, methods, analyses, models and measurements of cardiovascular research in a practical, “how-to-do-it” approach, resulting in clear-headed guidance to even the most complicated techniques and methods.

• Covers each technique or method beginning with an explanation of when and why it should be selected
followed by step-by-step instructions that include why each step is important; what can go wrong; how to trouble shoot and correct errors, and how to analyze and report results.

• Helps ensure research success, but also, critically, enables readers to understand why and how some experiments fail.

• Contains illustrative figures to reinforce the key components/steps of each method covered.

• Includes a companion website with video clips to support the discussion of particularly challenging techniques, for example animal surgical procedures.

Manual of Research Techniques in Cardiovascular Medicine is an invaluable resource for investigators at all levels, from technicians, students, fellows and other healthcare professionals who are approaching research for the first time, to seasoned investigators in cardiovascular disease, pharmacology, and related areas who need expert guidance on emerging techniques or unfamiliar models or methods.

About the Author

Edited by

Hossein Ardehali MD, PhD, FAHA, Associate Professor of Medicine, Molecular Pharmacology and Biological
Chemistry
Feinberg Cardiovascular Research Institute
Northwestern University
Feinberg School of
Medicine, Chicago, IL USA

Roberto Bolli MD
Professor of Medicine Chief, Division of Cardiovascular Medicine
Director, Institute of Molecular Cardiology
University of Louisville
Louisville, KY USA

Douglas W. Losordo MD
Vice President New Therapeutic Development
Baxter Healthcare Corporation
Deerfield, IL USA

 


Books with free ebook downloads available Manual of Research Techniques in Cardiovascular Medicine Hardcover – March 17, 2014
  • Hardcover: 472 pages
  • Publisher: Wiley-Blackwell; 1 edition (March 17, 2014)
  • Language: English
  • ISBN-10: 0470672692
  • ISBN-13: 978-0470672693
  • Product Dimensions: 10.1 x 7.2 x 1 inches
  • Shipping Weight: 2.6 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #364,963 in Books (See Top 100 in Books)

List of Contributors ix

Preface xix

About the Companion Website xx

Part 1 Electrophysiology

1 Measurement of calcium transient ex vivo 3
Kenneth R. Laurita and Bradley N. Plummer

2 Confocal imaging of intracellular calcium cycling in isolated cardiac myocytes 12
Søren Grubb, J. Andrew Wasserstrom, and Gary L. Aistrup

3 Generating a large animal model of persistent atrial fi brillation 20
Raphaël P. Martins and José Jalife

4 Confocal imaging of intracellular calcium cycling in the intact heart 32
Neha Singh, Manvinder Kumar, James E. Kelly, Gary L. Aistrup, and J. Andrew Wasserstrom

5 Recording and measurement of action potentials 41
Kenneth S. Ginsburg and Donald M. Bers

6 Patch-clamp recordings from isolated cardiac myocytes 50
Kai-Chien Yang, Wei Wang, and Jeanne M. Nerbonne

7 Optical mapping of the heart 60
Di Lang, Sarah Gutbrod, Jacob Laughner, and Igor R. Efi mov

Part 2 Isolation and Maintenance of Primary Stem Cells

8 Isolation of colony-forming endothelial progenitor cells 71
Haruchika Masuda and Takayuki Asahara

9 Cardiac resident stem cells 87
João Ferreira-Martins, Fumihiro Sanada, and Marcello Rota

10 Cardiospheres 95
Rachel Ruckdeschel Smith

11 Mesenchymal stem cells 104
Jose S. Da Silva and Joshua M. Hare

12 Generation and differentiation of human iPS cells 110
Sebastian Diecke, Lei Ye, Sophia Zhang, and Jianyi Zhang

13 Isolation of neonatal and adult rat cardiomyocytes 117
Md. Abdur Razzaque and Jeffrey Robbins

14 Isolation and culture of vascular smooth muscle cells 125
Milton Hamblin, Lin Chang, and Y. Eugene Chen

15 Isolation and culture of cardiac endothelial cells 131
Asish K. Ghosh, Joseph W. Covington, and Douglas E. Vaughan

16 Isolation and culture of cardiac fi broblasts 140
Asish K. Ghosh, Joseph W. Covington and Douglas E. Vaughan

17 Murine bone marrow transplantation model 146
Prasanna Krishnamurthy, Suresh Kumar Verma, and Raj Kishore

18 In vitro differentiation and expansion of vascular endothelial cells derived from mouse embryonic stem cells 149
Anees Fatima, Carey Nassano-Miller, and Tsutomu Kume

Part 3 Manipulation of the Heart and Vessels in Vivo and ex Vivo

19 Coronary ligation 157
Alexander R. Mackie and Hossein Ardehali

20 Transverse aortic constriction: a model to study heart failure in small animals 164
Suresh Kumar Verma, Prasanna Krishnamurthy, and Raj Kishore

21 Pharmacological models of hypertrophy and failure 170
Angela C. deAlmeida, Tariq Hamid, and Sumanth D. Prabhu

22 Hindlimb ischemia 177
Jerry C. Lee, Ngan F. Huang, and John P. Cooke

23 The Langendorff preparation 187
Hugh Clements-Jewery and Michael J. Curtis

24 Myocarditis and other immunological models of cardiac disease 197
Daniela C iháková and Noel R. Rose

25 Models of pacing-induced heart failure 203
James A. Shuman, Rupak Mukherjee, and Francis G. Spinale

26 Porcine myocardial ischemia models 215
Xian-Liang Tang and Roberto Bolli

27 Angiogenesis assays 225
Susmita Sahoo and Douglas W. Losordo

28 Immunohistochemical analysis of cardiac tissue 232
Barbara Ogórek, Donato Cappetta, and Jan Kajstura

29 A murine model of cardiac arrest by exsanguination 237
Guangming Cheng, Yiru Guo, Harold K. Elias, Carrie M. Quinn, Arash Davani, Yanjuan Yang, Magdy Girgis, Roberto Bolli, and Buddhadeb Dawn

Part 4 Small Animal Imaging

30 Blood pressure, telemetry, and vascular measurements in the rodent model 245
Robert S. Danziger

31 The setting: imaging conscious, sedated, or anesthetized rodents 250
Gene H. Kim and Roberto M. Lang

32 Echocardiography: standard techniques (M-mode, two-dimensional imaging, and Doppler) 254
Gene H. Kim, Lauren Beussink-Nelson, Sanjiv J. Shah, and Roberto M. Lang

33 Echocardiography: advanced techniques (tissue Doppler, speckle tracking, and three-dimensional imaging) 275
Lauren Beussink-Nelson, Gene H. Kim, Roberto M. Lang, and Sanjiv J. Shah

34 In vivo tomographic cardiac imaging: positron emission tomography and magnetic resonance imaging 287
Bruno C. Huber, Patricia K. Nguyen, and Joseph C. Wu

35 In vivo hemodynamics 295
Alexander R. Mackie, Kyle K. Henderson, Sol Misener, and Hossein Ardehali

Part 5 Metabolism, Mitochondria, and Cell Death

36 Fractionation of cardiomyocytes and isolation of mitochondria 307
Christopher P. Baines

37 Assessment of glucose and fatty acid metabolism ex vivo 313
Darrell D. Belke and E. Dale Abel

38 Quantification and characterization of atherosclerotic lesions in mice 320
Abhinav Agarwal, Millicent G. Winner, Srinivas D. Sithu, and Sanjay Srivastava

39 Assessment of cell death in the heart 332
Russell S. Whelan, Klitos Konstantinidis, and Richard N. Kitsis

40 Assessment of mitochondrial function in isolated cells 343
Amy K. Rines and Hossein Ardehali

41 Multinuclear NMR spectroscopy of myocardial energetics and substrate utilization in isolated perfused mouse hearts 351
Stephen C. Kolwicz, Jr. and Rong Tian

42 Measurement of reactive oxygen species in cardiovascular disease 359
Mahmood Khan, Fatemat Hassan, Sashwati Roy, and Chandan K. Sen

43 Assessing autophagy 371
Roberta A. Gottlieb

44 Assessment of cardiomyocyte size 378
A. Martin Gerdes and Alessandro Pingitore

Part 6 Manipulation of Gene Expression in Vitro and in Vivo

45 Generation of Cre-loxP mouse models for conditional knockout and overexpression of genes in various heart cells 389
Marisa Z. Jackson and Warren G. Tourtellotte

46 Modulation of myocardial genes via use of adenoviral vectors and RNA interference approaches 397
Qianhong Li

47 Overexpression and downregulation of proteins in vitro 407
Marina Bayeva and Hossein Ardehali

48 In vivo microRNA studies 416
Eva van Rooij

Part 7 Model Systems

49 Vascular and cardiac studies in zebrafi sh 425
Hans-Georg Simon, Molly Ahrens, and Brandon Holtrup

50 Vascular and cardiac studies in Drosophila 432
Lin Yu, Joseph P. Daniels, and Matthew J. Wolf

Index 441

Manual of Research Techniques in Cardiovascular Medicine – March 17, 2014 Download

Please Wait...
Friday, May 2, 2014

The Care and Feeding of an IACUC


The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee [Kindle Edition]

Author: Whitney Kayla Petrie M. Lawrence Podolsky Sonja Lea Wallace Victor Lukas | Language: English | ISBN: B0014B0TI2 | Format: PDF, EPUB

The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee
Posts about Download The Book The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee [Kindle Edition] for everyone book mediafire, rapishare, and mirror link The framers of the 1985 amendments to the Federal Animal Welfare Act (AWA) envisioned the Institutional Animal Care and Use Committee (IACUC) as the linchpin--the central and cohesive element--of the laboratory animal care and use program at research, education, and testing organizations. Effective operation of this committee is essential if these organizations are to achieve full regulatory compliance, and, more importantly, retain the public's support for activities involving the use of animal subjects.

In 1987, the Scientists Center for Animal Welfare, in cooperation with the American Association for Laboratory Animal Science, published a compilation of presentations made at five regional workshops on effective operation of IACUCs. In the decade since this compilation was published, nearly all of the 18 consensus recommendations developed by the workshop participants and the Center's Board of Trustees have either been incorporated into the AWA regulations or have been voluntarily adopted by institutions using animals subjects.

The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee superbly illustrates the progress and advances the animal-using communities have made in implementing these and other improvements in their animal care and use programs.

The highly qualified contributors provide twelve information-packed chapters and ten appendices that provide IACUC chairs and members with an indispensable reference. This book summarizes information critical to the effective and efficient management and operation of an IACUC, and, as such, should be made available to IACUC members and administrative officials in every institution using laboratory animals. Download latest books on mediafire and other links compilation The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee [Kindle Edition]
  • File Size: 2699 KB
  • Print Length: 216 pages
  • Publisher: CRC Press; 1 edition (March 25, 1999)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B0014B0TI2
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Not Enabled
  • Amazon Best Sellers Rank: #2,197,395 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee Download

Please Wait...

The Care and Feeding of an IACUC


The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee Hardcover – March 25, 1999

Author: Whitney Kayla Petrie | Language: English | ISBN: 0849325803 | Format: PDF, EPUB

The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee – March 25, 1999
Download books file now The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee – March 25, 1999 from mediafire, rapishare, and mirror link

Review

The chapters are pertinent…well written…a valuable addition to the library of any facility…Perhaps the greatest value in this book is its potential as a part of a training program for IACUC members.
- Contemporary Topics in Laboratory Animal Science, March 2000

Books with free ebook downloads available The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee – March 25, 1999
  • Hardcover: 216 pages
  • Publisher: CRC Press; 1 edition (March 25, 1999)
  • Language: English
  • ISBN-10: 0849325803
  • ISBN-13: 978-0849325809
  • Product Dimensions: 0.7 x 6.3 x 9.4 inches
  • Shipping Weight: 15.2 ounces (View shipping rates and policies)
  • Amazon Best Sellers Rank: #1,260,072 in Books (See Top 100 in Books)

The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee – March 25, 1999 Download

Please Wait...
Thursday, May 1, 2014

Evaluation Fundamentals


Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value [Paperback]

Author: Arlene G. Fink | Language: English | ISBN: 1452282005 | Format: PDF, EPUB

Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value
You can download Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value [Paperback] from mediafire, rapishare, and mirror link

The Third Edition of Arlene Fink’s Evaluation Fundamentals teaches the basic concepts and vocabulary necessary to do program evaluations and review the quality of evaluation research to make informed decisions about methods and outcomes to meet scientific and community needs. Dr. Fink thoroughly examines such issues as how to justify evaluation questions and set standards of effectiveness, design studies, identify best practices, and conduct ethical research. The book contains numerous examples of evaluation methods, as well as evaluation reports. It also includes practice exercises and suggested readings in print and online. Individuals can use the New Edition successfully on their own or in small or large groups.

 

“The text is extremely well organized. . . The concepts are easy to follow and the explanations are excellent.”

—Sharon K. Drake, Iowa State University

 

“Dr. Fink did an outstanding job of introducing concepts and practice of program evaluation in a way that anyone can understand. Those who are interested in program evaluation will enjoy this book regardless of their field of study.”

—Young Ik Cho, University of Wisconsin, Milwaukee

 

“The key strength of this book is the introduction of the key concepts, terms, and considerations that are needed for an evaluation study.  These introductions are concise, understandable, and in logical order.”

—Richard C. Maurer, University of Kentucky

Books with free ebook downloads available Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value [Paperback]
  • Paperback: 304 pages
  • Publisher: SAGE Publications, Inc; Third Edition edition (March 11, 2014)
  • Language: English
  • ISBN-10: 1452282005
  • ISBN-13: 978-1452282008
  • Product Dimensions: 9.1 x 7.4 x 0.6 inches
  • Shipping Weight: 1.1 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #373,790 in Books (See Top 100 in Books)

Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value Download

Please Wait...

Evaluation Fundamentals


Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value [Kindle Edition]

Author: Arlene G. Fink | Language: English | ISBN: B00JXZ2ZCO | Format: PDF, EPUB

Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value
Free download Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value [Kindle Edition] from mediafire, rapishare, and mirror link

The Third Edition of Arlene Fink’s Evaluation Fundamentals teaches the basic concepts and vocabulary necessary to do program evaluations and review the quality of evaluation research to make informed decisions about methods and outcomes to meet scientific and community needs. Dr. Fink thoroughly examines such issues as how to justify evaluation questions and set standards of effectiveness, design studies, identify best practices, and conduct ethical research. The book contains numerous examples of evaluation methods, as well as evaluation reports. It also includes practice exercises and suggested readings in print and online. Individuals can use the New Edition successfully on their own or in small or large groups.


 


“The text is extremely well organized. . . The concepts are easy to follow and the explanations are excellent.”


—Sharon K. Drake, Iowa State University


 


“Dr. Fink did an outstanding job of introducing concepts and practice of program evaluation in a way that anyone can understand. Those who are interested in program evaluation will enjoy this book regardless of their field of study.”


—Young Ik Cho, University of Wisconsin, Milwaukee


 


“The key strength of this book is the introduction of the key concepts, terms, and considerations that are needed for an evaluation study.  These introductions are concise, understandable, and in logical order.”


—Richard C. Maurer, University of Kentucky

Download latest books on mediafire and other links compilation Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value
  • File Size: 5792 KB
  • Print Length: 304 pages
  • Publisher: SAGE Publications, Inc; Third Edition edition (March 11, 2014)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B00JXZ2ZCO
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Not Enabled
  • Amazon Best Sellers Rank: #980,671 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Evaluation Fundamentals: Insights into Program Effectiveness, Quality, and Value Download

Please Wait...
Tuesday, April 29, 2014

Fast Facts for Curriculum Development in Nursing


Fast Facts for Curriculum Development in Nursing [Kindle Edition]

Author: | Language: English | ISBN: B0089VZ3YU | Format: PDF, EPUB

Fast Facts for Curriculum Development in Nursing
Download Fast Facts for Curriculum Development in Nursing from mediafire, rapishare, and mirror link

This new addition to the Fast Facts series is a pithy guide for novice nurse educators to the development, revision, and evaluation of programs and curricula that meet the standard requirements of the National Council of State Boards of Nursing, the NLNAC, and CCNE.

Applying the concepts and principles of Systems Theory, the guide moves through the development process to include evaluation procedures where decisions are based on data. It addresses the common definitions of curriculum, how to design a curriculum, and how to design courses in accordance with the organizing elements of the program. The guide covers the purposes and development of a mission statement and of a program philosophy, as well as how to select an organizational framework. Curriculum implementation and faculty development requirements are also explored, in addition to educational and program outcomes and their evaluation. Organized for quick access and ease of use, each chapter defines key terms, summarizes important points, and lists resources for additional study.

Key Features:

  • Designed for use by all nursing educators regardless of educational environment or type of learner
  • Breaks each step of the program development process into manageable parts that build on each other
  • Uses concepts and principles of Systems Theory to guide curriculum development and evaluation
  • Assists new nurse educators in quickly identifying the individual elements of a program and grasping the connections between them

Direct download links available for Fast Facts for Curriculum Development in Nursing [Kindle Edition]
  • File Size: 1698 KB
  • Print Length: 200 pages
  • Publisher: Springer Publishing Company; 1 edition (June 20, 2012)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B0089VZ3YU
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Not Enabled
  • Amazon Best Sellers Rank: #245,639 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
    • #22 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Medical eBooks > Nursing > Research & Theory
    • #26 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Medical eBooks > Nursing > Management, Leadership & Administration
    • #27 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Medical eBooks > Nursing > Issues, Trends & Roles
Outstanding book; well written and easy to understand. This should be required reading for all Curriculum Committee members in schools of nursing.
By Lynette M Savage
Recommend to fellow nursing faculty involved in curriculum and program development. Easy to read and follow. Like the "Fast Facts' series.
By sandra

Fast Facts for Curriculum Development in Nursing Download

Please Wait...

Fast Facts for Curriculum Development in Nursing


Fast Facts for Curriculum Development in Nursing: How to Develop & Evaluate Educational Programs in a Nutshell [Paperback]

Author: Amazon Prime | Language: English | ISBN: 0826109985 | Format: PDF, EPUB

Fast Facts for Curriculum Development in Nursing: How to Develop & Evaluate Educational Programs in a Nutshell
You can download Fast Facts for Curriculum Development in Nursing: How to Develop & Evaluate Educational Programs in a Nutshell [Paperback] for everyone book mediafire, rapishare, and mirror link

This new addition to the Fast Facts series is a pithy guide for novice nurse educators to the development, revision, and evaluation of programs and curricula that meet the standard requirements of the National Council of State Boards of Nursing, the NLNAC, and CCNE.

Applying the concepts and principles of Systems Theory, the guide moves through the development process to include evaluation procedures where decisions are based on data. It addresses the common definitions of curriculum, how to design a curriculum, and how to design courses in accordance with the organizing elements of the program. The guide covers the purposes and development of a mission statement and of a program philosophy, as well as how to select an organizational framework. Curriculum implementation and faculty development requirements are also explored, in addition to educational and program outcomes and their evaluation. Organized for quick access and ease of use, each chapter defines key terms, summarizes important points, and lists resources for additional study.

Key Features:

  • Designed for use by all nursing educators regardless of educational environment or type of learner
  • Breaks each step of the program development process into manageable parts that build on each other
  • Uses concepts and principles of Systems Theory to guide curriculum development and evaluation
  • Assists new nurse educators in quickly identifying the individual elements of a program and grasping the connections between them

Direct download links available for Fast Facts for Curriculum Development in Nursing: How to Develop & Evaluate Educational Programs in a Nutshell
  • Series: Fast Facts
  • Paperback: 200 pages
  • Publisher: Springer Publishing Company; 1 edition (June 20, 2012)
  • Language: English
  • ISBN-10: 0826109985
  • ISBN-13: 978-0826109989
  • Product Dimensions: 7.7 x 5 x 0.1 inches
  • Shipping Weight: 3.2 ounces (View shipping rates and policies)
  • Amazon Best Sellers Rank: #204,758 in Books (See Top 100 in Books)
    • #95 in Books > Textbooks > Medicine & Health Sciences > Nursing > Issues
Outstanding book; well written and easy to understand. This should be required reading for all Curriculum Committee members in schools of nursing.
By Lynette M Savage
Recommend to fellow nursing faculty involved in curriculum and program development. Easy to read and follow. Like the "Fast Facts' series.
By sandra

Fast Facts for Curriculum Development in Nursing: How to Develop & Evaluate Educational Programs in a Nutshell Download

Please Wait...
Monday, April 28, 2014

Making Sense of Qualitative Data


Making Sense of Qualitative Data: Complementary Research Strategies [Hardcover]

Author: | Language: English | ISBN: 0803970528 | Format: PDF, EPUB

Making Sense of Qualitative Data: Complementary Research Strategies
Download electronic versions of selected books Making Sense of Qualitative Data: Complementary Research Strategies [Hardcover] for everyone book with Mediafire Link Download Link
Once a research project has been designed and the data have been gathered, what is the best way to transform this information into something useful? The authors of this practical volume highlight the range of approaches available to qualitative researchers by using a single data set which they analyze using a number of techniques. With special attention paid to the possibilities in computer-aided analysis, this book will be an invaluable resource for the relatively new qualitative researcher.
Books with free ebook downloads available Making Sense of Qualitative Data: Complementary Research Strategies
  • Hardcover: 216 pages
  • Publisher: SAGE Publications, Inc (March 14, 1996)
  • Language: English
  • ISBN-10: 0803970528
  • ISBN-13: 978-0803970526
  • Product Dimensions: 9.5 x 6.5 x 0.8 inches
  • Shipping Weight: 1 pounds
  • Amazon Best Sellers Rank: #5,620,267 in Books (See Top 100 in Books)
I read this book as part of an advanced qualitative research methods course. This book is excellent and could be understood even by beginning researchers. The example data set is easy to follow and applicable to the ideas and points the authors are trying to make. Easy to read and follow and even more helpful if you have your own project/data to think about as you read. I am sure I will refer back to this book as I write my dissertation.
By M. ODonnell
This was required reading and as such it actually help me with the course of study. Hope it helps you too.
By Robert Holter

Making Sense of Qualitative Data: Complementary Research Strategies Download

Please Wait...
Sunday, April 27, 2014

Making Sense of Qualitative Data


Making Sense of Qualitative Data: Complementary Research Strategies [Paperback]

Author: Amazon Prime Sign in to turn on 1-Click ordering | Language: English | ISBN: 0803970536 | Format: PDF, EPUB

Making Sense of Qualitative Data: Complementary Research Strategies
Free download Making Sense of Qualitative Data: Complementary Research Strategies from mediafire, rapishare, and mirror link
Once a research project has been designed and the data have been gathered, what is the best way to transform this information into something useful? The authors of this practical volume highlight the range of approaches available to qualitative researchers by using a single data set which they analyze using a number of techniques. With special attention paid to the possibilities in computer-aided analysis, this book will be an invaluable resource for the relatively new qualitative researcher.
Download latest books on mediafire and other links compilation Making Sense of Qualitative Data: Complementary Research Strategies [Paperback]
  • Paperback: 216 pages
  • Publisher: SAGE Publications, Inc; 1 edition (March 14, 1996)
  • Language: English
  • ISBN-10: 0803970536
  • ISBN-13: 978-0803970533
  • Product Dimensions: 9.1 x 6 x 0.6 inches
  • Shipping Weight: 13.4 ounces (View shipping rates and policies)
  • Amazon Best Sellers Rank: #179,987 in Books (See Top 100 in Books)
I read this book as part of an advanced qualitative research methods course. This book is excellent and could be understood even by beginning researchers. The example data set is easy to follow and applicable to the ideas and points the authors are trying to make. Easy to read and follow and even more helpful if you have your own project/data to think about as you read. I am sure I will refer back to this book as I write my dissertation.
By M. ODonnell
This was required reading and as such it actually help me with the course of study. Hope it helps you too.
By Robert Holter

Making Sense of Qualitative Data: Complementary Research Strategies Download

Please Wait...
Saturday, April 26, 2014

In Vitro Toxicology Systems – May 1, 2014


In Vitro Toxicology Systems (Methods in Pharmacology and Toxicology) Hardcover – May 1, 2014

Author: Anna Bal-Price | Language: English | ISBN: 1493905201 | Format: PDF, EPUB

In Vitro Toxicology Systems – May 1, 2014
Download for free books In Vitro Toxicology Systems (Methods in Pharmacology and Toxicology) Hardcover – May 1, 2014 for everyone book mediafire, rapishare, and mirror link

From the Back Cover

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.

Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.


Books with free ebook downloads available In Vitro Toxicology Systems – May 1, 2014
  • Series: Methods in Pharmacology and Toxicology
  • Hardcover: 583 pages
  • Publisher: Humana Press; 2014 edition (May 1, 2014)
  • Language: English
  • ISBN-10: 1493905201
  • ISBN-13: 978-1493905201
  • Product Dimensions: 10 x 7.3 x 1.5 inches
  • Shipping Weight: 2.8 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #1,391,145 in Books (See Top 100 in Books)

In Vitro Toxicology Systems – May 1, 2014 Download

Please Wait...
Thursday, April 24, 2014

Basic Allied Health Statistics and Analysis Spiral-bound – March 11, 2014


Basic Allied Health Statistics and Analysis Spiral-bound – March 11, 2014

Author: Visit Amazon's Gerda Koch Page | Language: English | ISBN: 1133602703 | Format: PDF, EPUB

Basic Allied Health Statistics and Analysis Spiral-bound – March 11, 2014
Download electronic versions of selected books Basic Allied Health Statistics and Analysis Spiral-bound – March 11, 2014 for everyone book mediafire, rapishare, and mirror link

Review

"The beginning review chapters are a great overview for students that have not had math in recent years, layout & organization of information in the text is easy to follow, self-tests and chapter tests are very good practice for students." - Kelly Rinker, RHIA, CPHIMS, Faculty, Regis University

"I will never use another book besides the Koch book - it is excellent." - Cindy Fickenscher, MBA, RHIA, Program Director/Instructor, Health Information Technology Program, Gateway Technical College

About the Author

Gerda Koch is a retired Assistant Professor in the Medical Assistant Program at Illinois State University in Normal, Illinois. Her career in Health Information Management and education spans more than 30 years.

Books with free ebook downloads available Basic Allied Health Statistics and Analysis Spiral-bound – March 11, 2014
  • Spiral-bound: 368 pages
  • Publisher: Cengage Learning; 4 edition (March 11, 2014)
  • Language: English
  • ISBN-10: 1133602703
  • ISBN-13: 978-1133602705
  • Product Dimensions: 10.7 x 9 x 0.9 inches
  • Shipping Weight: 1.9 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #182,076 in Books (See Top 100 in Books)

Basic Allied Health Statistics and Analysis Spiral-bound – March 11, 2014 Download

Please Wait...
Wednesday, April 23, 2014

Basic Allied Health Statistics and Analysis


Basic Allied Health Statistics and Analysis [Plastic Comb]

Author: Gerda Koch | Language: English | ISBN: 0766810925 | Format: PDF, EPUB

Basic Allied Health Statistics and Analysis
Download for free books Basic Allied Health Statistics and Analysis [Plastic Comb] for everyone book 4shared, mediafire, hotfile, and mirror link
This comprehensive text uses a discussion and problem-solving format to introduce learners to the computational skills required in the health care field. The hands-on approach challenges learners to think through a problem and choose the appropriate data, helping them to understand its underlying concepts. It also stresses the importance of evaluating the source of the data and how the rates are obtained. The second edition includes a chapter on computerized rates and graphing. This introductory text teaches allied health students the computational skills they need to be successful.
Direct download links available for Basic Allied Health Statistics and Analysis
  • Series: Basic Allied Health Statistics And Analysis
  • Plastic Comb: 288 pages
  • Publisher: Delmar Cengage Learning; 2 edition (November 23, 1999)
  • Language: English
  • ISBN-10: 0766810925
  • ISBN-13: 978-0766810921
  • Product Dimensions: 11.1 x 8.9 x 0.8 inches
  • Shipping Weight: 1.6 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #1,818,344 in Books (See Top 100 in Books)
This book makes stats much easier to swallow. Excellent chapter exercises to apply the learning, although, sometimes the formulas and answers don't seem consistent so I wonder if I got an early version before addt; edits and corrections were made.

Great book to use and apply in the real health care work environment.
By Roberta J. Aberle
It was listed as new, but it was used. There writing on almost all the pages and some pages had stains on them and were wrinkled.
By Titus A. Thompson

Basic Allied Health Statistics and Analysis Download

Please Wait...

Basic Allied Health Statistics and Analysis


Basic Allied Health Statistics and Analysis [Print Replica] [Kindle Edition]

Author: Gerda Koch | Language: English | ISBN: B00B90GPKE | Format: PDF, EPUB

Basic Allied Health Statistics and Analysis
Download for free books Basic Allied Health Statistics and Analysis for everyone book 4shared, mediafire, hotfile, and mirror link This comprehensive resource is designed to explain how statistics are computed and applied in health care settings. The hands-on method requires you to think through a problem and choose the appropriate data to apply. Detailed examples and numerous practice opportunities present a step-by-step learning path that encourages mastery of concepts.
Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
Download latest books on mediafire and other links compilation Basic Allied Health Statistics and Analysis
  • File Size: 4126 KB
  • Print Length: 360 pages
  • Publisher: Cengage Learning; 3rd edition (September 24, 2013)
  • Sold by: Cengage Learning
  • Language: English
  • ASIN: B00B90GPKE
  • Text-to-Speech: Not enabled
  • X-Ray for Textbooks:
    Enabled
  • Lending: Not Enabled
  • Amazon Best Sellers Rank: #1,270,869 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
This book makes stats much easier to swallow. Excellent chapter exercises to apply the learning, although, sometimes the formulas and answers don't seem consistent so I wonder if I got an early version before addt; edits and corrections were made.

Great book to use and apply in the real health care work environment.
By Roberta J. Aberle
It was listed as new, but it was used. There writing on almost all the pages and some pages had stains on them and were wrinkled.
By Titus A. Thompson

Basic Allied Health Statistics and Analysis Download

Please Wait...
Tuesday, April 22, 2014

Basic Allied Health Statistics and Analysis, 3rd Edition Spiral-bound – March 4, 2008


Basic Allied Health Statistics and Analysis, 3rd Edition Spiral-bound – March 4, 2008

Author: Visit Amazon's Gerda Koch Page | Language: English | ISBN: 142832089X | Format: PDF, EPUB

Basic Allied Health Statistics and Analysis, 3rd Edition Spiral-bound – March 4, 2008
Download electronic versions of selected books Basic Allied Health Statistics and Analysis, 3rd Edition Spiral-bound – March 4, 2008 for everyone book with Mediafire Link Download Link

Review

Chapter 1: Statistical Terminology and Health Care Data Chapter 2: Health Care Overview and Patient Data Collection Chapter 3: Mathematical Review Chapter 4: Census Chapter 5: Percent of Occupancy Chapter 6: Length of Stay/Discharge Days Chapter 7: Hospital Mortality Rates Chapter 8: Obstetrical-Related Rates Chapter 9: Autopsy Rates Chapter 10: Miscellaneous Rates Chapter 11: Vital Statistics Data/Rates Chapter 12: Frequency Distribution Chapter 13: Measures of Central Tendency and Variation Chapter 14: Data Presentation Appendix I: Glossary Appendix II: Formulae Appendix III: Abbreviations Appendix IV: Answers to the Self-Tests & Chapter Tests Appendix V: Quick Reference Service Classification Categories

About the Author

Gerda Koch is a retired Assistant Professor in the Medical Assistant Program at Illinois State University in Normal, Illinois. Her career in Health Information Management and education spans more than 30 years.

Books with free ebook downloads available Basic Allied Health Statistics and Analysis, 3rd Edition Spiral-bound – March 4, 2008
  • Series: Basic Allied Health Statistics And Analysis
  • Spiral-bound: 360 pages
  • Publisher: Cengage Learning; 3rd edition (March 4, 2008)
  • Language: English
  • ISBN-10: 142832089X
  • ISBN-13: 978-1428320895
  • Product Dimensions: 10.7 x 8.9 x 0.9 inches
  • Shipping Weight: 1.8 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #229,284 in Books (See Top 100 in Books)

Basic Allied Health Statistics and Analysis, 3rd Edition Spiral-bound – March 4, 2008 Download

Please Wait...
Monday, April 21, 2014

Clinical Trials with Missing Data


Clinical Trials with Missing Data: A Guide for Practitioners (Statistics in Practice) [Kindle Edition]

Author: Michael O'Kelly | Language: English | ISBN: B00IIO8FK2 | Format: PDF, EPUB

Clinical Trials with Missing Data: A Guide for Practitioners
You can download Clinical Trials with Missing Data: A Guide for Practitioners for everyone book mediafire, rapishare, and mirror link

This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable.

The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively.

The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.

Direct download links available for Clinical Trials with Missing Data: A Guide for Practitioners
  • File Size: 4625 KB
  • Print Length: 472 pages
  • Publisher: Wiley; 1 edition (February 14, 2014)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B00IIO8FK2
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Enabled
  • Amazon Best Sellers Rank: #625,942 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Clinical Trials with Missing Data: A Guide for Practitioners Download

Please Wait...
Sunday, April 20, 2014

Clinical Trials with Missing Data


Clinical Trials with Missing Data: A Guide for Practitioners (Statistics in Practice) [Hardcover]

Author: Michael O'Kelly | Language: English | ISBN: 1118460707 | Format: PDF, EPUB

Clinical Trials with Missing Data: A Guide for Practitioners
Download Clinical Trials with Missing Data: A Guide for Practitioners for everyone book 4shared, mediafire, hotfile, and mirror link

This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable.

The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively.

The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.

Books with free ebook downloads available Clinical Trials with Missing Data: A Guide for Practitioners
  • Series: Statistics in Practice
  • Hardcover: 472 pages
  • Publisher: Wiley; 1 edition (April 7, 2014)
  • Language: English
  • ISBN-10: 1118460707
  • ISBN-13: 978-1118460702
  • Product Dimensions: 9.8 x 6.7 x 1.3 inches
  • Shipping Weight: 1.5 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #1,107,843 in Books (See Top 100 in Books)

Preface xv

References xvii

Acknowledgments xix

Notation xxi

Table of SAS code fragments xxv

Contributors xxix

1 What’s the problem with missing data? 1
Michael O’Kelly and Bohdana Ratitch

1.1 What do we mean by missing data? 2

1.1.1 Monotone and non-monotone missing data 3

1.1.2 Modeling missingness, modeling the missing value and ignorability 4

1.1.3 Types of missingness (MCAR, MAR and MNAR) 4

1.1.4 Missing data and study objectives 5

1.2 An illustration 6

1.3 Why can’t I use only the available primary endpoint data? 7

1.4 What’s the problem with using last observation carried forward? 9

1.5 Can we just assume that data are missing at random? 11

1.6 What can be done if data may be missing not at random? 14

1.7 Stress-testing study results for robustness to missing data 15

1.8 How the pattern of dropouts can bias the outcome 15

1.9 How do we formulate a strategy for missing data? 16

1.10 Description of example datasets 18

1.10.1 Example dataset in Parkinson’s disease treatment 18

1.10.2 Example dataset in insomnia treatment 23

1.10.3 Example dataset in mania treatment 28

Appendix 1.A: Formal definitions of MCAR, MAR and MNAR 33

References 34

2 The prevention of missing data 36
Sara Hughes

2.1 Introduction 36

2.2 The impact of “too much” missing data 37

2.2.1 Example from human immunodeficiency virus 38

2.2.2 Example from acute coronary syndrome 38

2.2.3 Example from studies in pain 39

2.3 The role of the statistician in the prevention of missing data 39

2.3.1 Illustrative example from HIV 41

2.4 Methods for increasing subject retention 48

2.5 Improving understanding of reasons for subject withdrawal 49

Acknowledgments 49

Appendix 2.A: Example protocol text for missing data prevention 49

References 50

3 Regulatory guidance – a quick tour 53
Michael O’Kelly

3.1 International conference on harmonization guideline: Statistical principles for clinical trials: E9 54

3.2 The US and EU regulatory documents 55

3.3 Key points in the regulatory documents on missing data 55

3.4 Regulatory guidance on particular statistical approaches 57

3.4.1 Available cases 57

3.4.2 Single imputation methods 57

3.4.3 Methods that generally assume MAR 59

3.4.4 Methods that are used assuming MNAR 60

3.5 Guidance about how to plan for missing data in a study 62

3.6 Differences in emphasis between the NRC report and EU guidance documents 63

3.6.1 The term “conservative” 63

3.6.2 Last observation carried forward 63

3.6.3 Post hoc analyses 63

3.6.4 Non-monotone or intermittently missing data 63

3.6.5 Assumptions should be readily interpretable 65

3.6.6 Study report 65

3.6.7 Training 65

3.7 Other technical points from the NRC report 66

3.7.1 Time-to-event analyses 66

3.7.2 Tipping point sensitivity analyses 66

3.8 Other US/EU/international guidance documents that refer to missing data 66

3.8.1 Committee for medicinal products for human use guideline on anti-cancer products, recommendations on survival analysis 66

3.8.2 US guidance on considerations when research supported by office of human research protections is discontinued 67

3.8.3 FDA guidance on data retention 67

3.9 And in practice? 67

References 69

4 A guide to planning for missing data 71
Michael O’Kelly and Bohdana Ratitch

4.1 Introduction 72

4.1.1 Missing data may bias trial results or make them more difficult to generalize to subjects outside the trial 72

4.1.2 Credibility of trial results when there is missing data 74

4.1.3 Demand for better practice with regard to missing data 74

4.2 Planning for missing data 76

4.2.1 The case report form and non-statistical sections of the protocol 76

4.2.2 The statistical sections of the protocol and the statistical analysis plan 81

4.2.3 Using historic data to narrow the choice of primary analysis and sensitivity analyses 88

4.2.4 Key points in choosing an approach for missing data 108

4.3 Exploring and presenting missingness 113

4.4 Model checking 114

4.5 Interpreting model results when there is missing data 116

4.6 Sample size and missing data 117

Appendix 4.A: Sample protocol/SAP text for study in Parkinson’s disease 119

Appendix 4.B: A formal definition of a sensitivity parameter 125

References 126

5 Mixed models for repeated measures using categorical time effects (MMRM) 130
Sonia Davis

5.1 Introduction 131

5.2 Specifying the mixed model for repeated measures 132

5.2.1 The mixed model 132

5.2.2 Covariance structures 135

5.2.3 Mixed model for repeated measures versus generalized estimating equations 139

5.2.4 Mixed model for repeated measures versus last observation carried forward 140

5.3 Understanding the data 141

5.3.1 Parkinson’s disease example 141

5.3.2 A second example showing the usefulness of plots: The CATIE study 144

5.4 Applying the mixed model for repeated measures 145

5.4.1 Specifying the model 146

5.4.2 Interpreting and presenting results 150

5.5 Additional mixed model for repeated measures topics 162

5.5.1 Treatment by subgroup and treatment by site interactions 162

5.5.2 Calculating the effect size 164

5.5.3 Another strategy to model baseline 166

5.6 Logistic regression mixed model for repeated measures using the generalized linear mixed model 168

5.6.1 The generalized linear mixed model 168

5.6.2 Specifying the model 170

5.6.3 Interpreting and presenting results 173

5.6.4 Other modeling options 181

References 182

Table of SAS Code Fragments 183

6 Multiple imputation 185
Bohdana Ratitch

6.1 Introduction 185

6.1.1 How is multiple imputation different from single imputation? 186

6.1.2 How is multiple imputation different from maximum likelihood methods? 187

6.1.3 Multiple imputation’s assumptions about missingness mechanism 188

6.1.4 A general three-step process for multiple imputation and inference 189

6.1.5 Imputation versus analysis model 190

6.1.6 Note on notation use 192

6.2 Imputation phase 192

6.2.1 Missing patterns: Monotone and non-monotone 192

6.2.2 How do we get multiple imputations? 195

6.2.3 Imputation strategies: Sequential univariate versus joint multivariate 197

6.2.4 Overview of the imputation methods 199

6.2.5 Reusing the multiply-imputed dataset for different analyses or summary scales 212

6.3 Analysis phase: Analyzing multiple imputed datasets 213

6.4 Pooling phase: Combining results from multiple datasets 216

6.4.1 Combination rules 216

6.4.2 Pooling analyses of continuous outcomes 219

6.4.3 Pooling analyses of categorical outcomes 222

6.5 Required number of imputations 227

6.6 Some practical considerations 231

6.6.1 Choosing an imputation model 231

6.6.2 Multivariate normality 235

6.6.3 Rounding and restricting the range for the imputed values 238

6.6.4 Convergence of Markov chain Monte Carlo 240

6.7 Pre-specifying details of analysis with multiple imputation 244

Appendix 6.A: Additional methods for multiple imputation 245

References 251

Table of SAS Code Fragments 255

7 Analyses under missing-not-at-random assumptions 257
Michael O’Kelly and Bohdana Ratitch

7.1 Introduction 258

7.2 Background to sensitivity analyses and pattern-mixture models 259

7.2.1 The purpose of a sensitivity analysis 259

7.2.2 Pattern-mixture models as sensitivity analyses 261

7.3 Two methods of implementing sensitivity analyses via pattern-mixture models 264

7.3.1 A sequential method of implementing pattern-mixture models with multiple imputation 264

7.3.2 Providing stress-testing “what ifs” using pattern-mixture models 266

7.3.3 Two implementations of pattern-mixture models for sensitivity analyses 267

7.3.4 Characteristics and limitations of the sequential modeling method of implementing pattern-mixture models 268

7.3.5 Pattern-mixture models implemented using the joint modeling method 271

7.3.6 Characteristics of the joint modeling method of implementing pattern-mixture models 279

7.3.7 Summary of differences between the joint modeling and sequential modeling methods 281

7.4 A “toolkit”: Implementing sensitivity analyses via SAS 284

7.4.1 Reminder: General approach using multiple imputation with regression 284

7.4.2 Sensitivity analyses assuming withdrawals have trajectory of control arm 288

7.4.3 Sensitivity analyses assuming withdrawals have distribution of control arm 292

7.4.4 Baseline-observation-carried-forward-like and last-observation-carried-forward-like analyses 297

7.4.5 The general principle of using selected subsets of observed data as the basis to implement “what if” stress tests 306

7.4.6 Using a mixture of “what ifs,” depending on reason for discontinuation 306

7.4.7 Assuming trajectory of withdrawals is worse by some ��: Delta adjustment and tipping point analysis 308

7.5 Examples of realistic strategies and results for illustrative datasets of three indications 320

7.5.1 Parkinson’s disease 320

7.5.2 Insomnia 323

7.5.3 Mania 330

Appendix 7.A How one could implement the neighboring case missing value assumption using visit-by-visit multiple imputation 335

Appendix 7.B SAS code to model withdrawals from the experimental arm, using observed data from the control arm 336

Appendix 7.C SAS code to model early withdrawals from the experimental arm, using the last-observation-carried-forward-like values 342

Appendix 7.D SAS macro to impose delta adjustment on a responder variable in the mania dataset 345

Appendix 7.E SAS code to implement tipping point via exhaustive scenarios for withdrawals in the mania dataset 346

Appendix 7.F SAS code to perform sensitivity analyses for the Parkinson’s disease dataset 348

Appendix 7.G SAS code to perform sensitivity analyses for the insomnia dataset 351

Appendix 7.H SAS code to perform sensitivity analyses for the mania dataset 356

Appendix 7.I Selection models 358

Appendix 7.J Shared parameter models 362

References 365

Table of SAS Code Fragments 368

8 Doubly robust estimation 369
Belinda Hern´andez, Ilya Lipkovich and Michael O’Kelly

8.1 Introduction 370

8.2 Inverse probability weighted estimation 370

8.2.1 Inverse probability weighting estimators for estimating equations 372

8.2.2 Summary of inverse probability weighting advantages 373

8.2.3 Inverse probability weighting disadvantages 373

8.3 Doubly robust estimation 374

8.3.1 Doubly robust methods explained 375

8.3.2 Advantages of doubly robust methods 376

8.3.3 Limitations of doubly robust methods 376

8.4 Vansteelandt et al. method for doubly robust estimation 377

8.4.1 Theoretical justification for the Vansteelandt et al. method 378

8.4.2 Implementation of the Vansteelandt et al. method for doubly robust estimation 379

8.5 Implementing the Vansteelandt et al. method via SAS 383

8.5.1 Mania dataset 383

8.5.2 Insomnia dataset 390

Appendix 8.A How to implement Vansteelandt et al. method for mania dataset (binary response) 392

Appendix 8.B SAS code to calculate estimates from the bootstrapped datasets 400

Appendix 8.C How to implement Vansteelandt et al. method for insomnia dataset 401

References 408

Table of SAS Code Fragments 408

Bibliography 409

Index 423

Clinical Trials with Missing Data: A Guide for Practitioners Download

Please Wait...
Friday, April 18, 2014

Clinical Trial Design


Clinical Trial Design: Bayesian and Frequentist Adaptive Methods (Wiley Series in Probability and Statistics) [Kindle Edition]

Author: Guosheng Yin | Language: English | ISBN: B00DAB1F8W | Format: PDF, EPUB

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods
Download books file now Clinical Trial Design: Bayesian and Frequentist Adaptive Methods (Wiley Series in Probability and Statistics) [Kindle Edition] for everyone book 4shared, mediafire, hotfile, and mirror link A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods

There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics.

Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include:

  • Risk and benefit analysis for toxicity and efficacy trade-offs

  • Bayesian predictive probability trial monitoring

  • Bayesian adaptive randomization

  • Late onset toxicity and response

  • Dose finding in drug combination trials

  • Targeted therapy designs

The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials.

Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

Books with free ebook downloads available Clinical Trial Design: Bayesian and Frequentist Adaptive Methods (Wiley Series in Probability and Statistics) [Kindle Edition]
  • File Size: 6001 KB
  • Print Length: 364 pages
  • Publisher: Wiley; 1 edition (June 7, 2013)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B00DAB1F8W
  • Text-to-Speech: Enabled
  • X-Ray:
    Not Enabled
  • Lending: Enabled
  • Amazon Best Sellers Rank: #1,425,402 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods Download

Please Wait...